Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010 Article
Author(s): De Leo D.,Lim S.S.,Shahraz S.,Miller T.R.,Wulf S.,Grant B.,Gabbe B.J.,Finucane M.M.,Carmona L.,Mocumbi A.O.,Rehm J.T.,Popova S.,Zheng Z.-J.,Flaxman A.D.,Taylor W.J.,Tavakkoli M.,Cella C.,Ezzati M.,Ferri C.P.,Towbin J.A.,Van Os J.,Duber H.,Mitchell P.B.,Bolliger I.,Shivakoti R.,Stolk W.A.,Bhandari B.,Lathlean T.,Thurston G.D.,Narayan K.M.V.,Naidoo K.,Truelsen T.,Singleton J.,Felson D.T.,Wilkinson J.D.,Grainger R.,James S.L.,Ibeanusi S.E.,Whiteford H.,Saha S.,Denenberg J.,Flaxman S.,Ebel B.,Bernabé E.,Jacobsen K.H.,Porrini E.,Rivara F.P.,Shepard D.S.,Freeman M.K.,Ackerman I.,Nair M.N.,Fransen M.,McAnulty J.H.,Steer A.,Hill C.,Witt E.,O'Hanlon S.,Meltzer M.,Corriere M.,Cooper L.T.,Michaud C.,Murdoch M.E.,Derrett S.,Gaspari F.,Zaidi A.K.M.,Polinder S.,Colan S.D.,Rivero A.P.,Nolte S.,Mayosi B.M.,Foreman K.,Gmel G.,Roberts T.,Flood L.,Benjamin E.J.,Weissman M.M.,Chugh S.S.,Buchbinder R.,Nevitt M.C.,Braithwaite T.,Hoffman H.,Rein D.B.,Dherani M.,Mwaniki M.K.,Farzadfar F.,Salomon J.A.,Boufous S.,Ramaiah K.D.,Espindola P.,Smith E.,Wiersma S.T.,Marks R.,Naldi L.,Anderson H.R.,Dorsey E.R.,Cheng A.T.-A.,Matzopoulos R.,Medina-Mora M.E.,Chen H.,Dabhadkar K.C.,Weintraub R.,Wang W.,Murray C.J.L.,Kawakami N.,Groeger J.,Dharmaratne S.D.,Connor M.D.,Carabin H.,Andrews K.G.,Gakidou E.,Naghavi M.,Bartels D.H.,Karthikeyan G.,Rosenfeld L.C.,Edmond K.,Steiner T.,Sacco R.L.,Jonas J.B.,Wolfe F.,Feigin V.,De Vaccaro K.C.,Mallinger L.,McGill N.,McDermott M.M.,Colquhoun S.,Zonies D.,Ali M.K.,Watt K.,Monasta L.,Taylor J.A.,Nelson R.G.,Ferrari A.,Condon J.,Blencowe H.,Remuzzi G.,Baddour L.M.,Havmoeller R.,Jarvis D.,Aboyans V.,Robinson C.,Degenhardt L.,Room R.,Lee Y.Y.,Fowkes F.G.R.,Hoy D.,De Leòn F.R.,Knowlton L.M.,Van Der Werf M.J.,Thomas B.,Koranteng A.,Miglioli V.,Perez-Ruiz F.,Ortblad K.,Phillips M.R.,Fèvre E.M.,Singh J.A.,Mokdad A.A.,Hoen B.,Erwin P.J.,Scott J.G.,Merriman T.R.,Kassebaum N.,Gosselin R.,Barker-Collo S.,Ma J.,Brugha T.S.,Anderson L.M.,Burstein R.,Higashi H.,Morawska L.,White R.A.,Driscoll T.,Phillips D.,Wiebe N.,Bonaventure A.,Vos T.,Cortinovis M.,Boussinesq M.,Weatherall D.J.,Bucello C.,Sudfeld C.,Matsumori A.,Khoo J.-P.,Weinstock M.A.,Tleyjeh I.M.,Pearce N.,Schwebel D.C.,Ronfani L.,Moran A.,Carapetis J.,Rushton L.,Ozgediz D.,Bryan-Hancock C.,Bikbov B.,Pourmalek F.,Malekzadeh R.,Aggarwal R.,Criqui M.H.,Hay R.J.,Norman P.,Patten S.B.,Davis A.,Vavilala M.S.,Abraham J.,Campbell B.,Page A.,Kobusingye O.,Bridgett L.,Pesudovs K.,Pope III C.A.,Brayne C.,Sanchez-Riera L.,Cowie B.C.,Shibuya K.,Omer S.B.,Mabweijano J.,Ganatra H.A.,Colson K.E.,Blore J.D.,Moradi-Lakeh M.,Leasher J.L.,Jayaraman S.,Norman R.,Lin J.K.,Gupta R.,Venketasubramanian N.,Lozano R.,Alvarado M.,Montico M.,Manivannan S.,Haring D.,Halasa Y.A.,Atkinson C.,Newton C.R.,Williams S.R.M.,Pahari B.,Laden F.,Lyons R.,Baxter A.,Stapelberg N.J.C.,Bhalla K.,Ahn S.Y.,Gonzalez-Medina D.,Shin H.,Sliwa K.,Lopez A.D.,Des Jarlais D.C.,Margolis D.J.,Erskine H.,Meyer A.-C.,Pion S.,Barrero L.H.,Dahodwala N.,Segui-Gomez M.,Burney P.,Basáñez M.-G.,Gillum R.F.,McGrath J.,Gunnell D.,Miller M.,Moffitt T.E.,Abdulhak A.B.,Ohno S.L.,Budke C.M.,Marks G.B.,Osborne R.,Bennett D.,Danaei G.,Hagan H.,Guillemin F.,Leigh J.,Tsilimbaris M.K.,Ewoigbokhan S.E.,Pullan R.L.,Tamburlini G.,Jasrasaria R.,Richardson K.,Lipnick M.,Damsere-Derry J.,Chou D.,Pandian J.D.,Regan M.,Taylor H.R.,Pierce K.,Brooker S.,Johns N.,Diaz-Torne C.,Nelson P.K.,Ali S.E.,Singh D.,Birbeck G.,O'Donnell M.,Coffeng L.E.,Bourne R.,King C.H.,Yeh P.-H.,Singh G.M.,Undurraga E.A.,Canter C.E.,Franklin R.,Loane M.,Mori R.,Harrison J.E.,Krishnamurthi R.,Smith J.L.,Ranganathan D.,MacIntyre M.F.,Charlson F.,Mock C.,Black J.A.,Sampson U.,Calabria B.,Stovner L.J.,Brooks P.,Limb E.,Bell M.L.,Lalloo R.,Bahalim A.N.,Burch M.,Mensah G.A.,Keren A.,March L.,Prince M.,Dolk H.,Padilla R.P.,Haro J.M.,Sanman E.,Razavi H.,Gabriel S.E.,Forouzanfar M.H.,Laslett L.L.,Liu W.,Haagsma J.,Thomson W.M.,Woolf A.D.,Hotez P.J.,Wang M.,Levinson D.,Dahiya M.,Delossantos A.,Lipshultz S.E.,Polanczyk G.V.,Perico N.,Elbaz A.,Ubeda C.,Syed S.,Buckle G.,Sleet D.A.,Marcenes W.,Tonelli M.,Weisskopf M.G.,Huang J.J.,Williams H.C.,Couser W.,Garcia B.,Olives C.,Blyth F.,Cross M.,Abdalla S.,Hall W.,Dellavalle R.
The Lancet Volume 380, Issue 9859, 2012 , Pages 2163-2196

Background: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither eff ort quantified uncertainty in prevalence or years lived with disability (YLDs). Methods: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. Findings: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. Interpretation: Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Eff ective and aff ordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.
systematic review hematologic disease newborn newborn disease sex difference Humans drowning anemia cardiovascular disease malaria years lived with disability Infant, Newborn low back pain health survey communicable disease liver cirrhosis disability age distribution quality adjusted life year priority journal maternal disease incidence infection statistics comorbidity diabetes mellitus disease severity very elderly documentation hospital discharge male human Child injury automutilation Prevalence mental disease health Aged, 80 and over tuberculosis ambulatory care disaster remission Infant young adult digestive system disease population growth violence child anti human immunodeficiency virus agent musculoskeletal disease Global Burden of Disease prevalence health status female adolescent endocrine disease Sex Factors chronic obstructive lung disease aged tropical disease disease registry Aged aging Human immunodeficiency virus infection disability severity article neoplasm war iatrogenic disease World Health Age Factors migraine Female Middle Aged diarrhea Male health care system anxiety disorder cancer registry iron deficiency anemia age infant meningitis neurologic disease antiviral therapy neck pain preschool child legal aspect major depression Quality-Adjusted Life Years falling Health Status behavior disorder Young Adult Adult acquired immune deficiency syndrome nutritional deficiency traffic accident lower respiratory tract infection disease duration adult clinical research middle aged Incidence Adolescent mortality outcome assessment Wounds and Injuries seroepidemiology urogenital tract disease Child, Preschool attitude to disability

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