Purpose: To evaluate the efficacy and safety of the Artisan Phakic Intraocular Lens (PIOL) for the correction of high myopia. Methods: In this prospective study of 22 eyes of 14 patients with high myopia, Artisan PIOLs (Ophtec BV) were implanted. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refraction, astigmatism, safety, and predictability were analyzed. Results: The mean of preoperative spherical equivalent was -11.1±3.3 D. An Artisan myopia lens was implanted in 28 eyes of 14 patients with preoperative myopia ranging from -6.0 to -20.0 D. The mean of patient age was 22.7±4.3 years. At three months follow-up, all eyes had a postoperative refraction within2+1 D emmetropia. Mean uncorrected visual acuity improved from less than 20/200 to 20/50, and mean best corrected visual acuity improved from 20/39 to 20/30. The mean endothelial cell loss was 4.45% at three months, which was not significant. Postoperative complications included anterior chamber reaction in 10 (45%) patients that resolved with medical treatment in all of them. No other serious complications developed in any of the treated eyes during follow-up period. Conclusion: Artisan PIOLs can correct moderate to high myopia with good refractive results. There were no serious complications in this study.