Author(s)
Faghihi K. Barati A. Mirzakhanian Z. Momeni H.R.

Title: Synthesis and characterization of fast-swelling porous superabsorbent hydrogel based on starch as a hemostatic agent

Author(s): Faghihi K.,Barati A.,Mirzakhanian Z.,Momeni H.R.
منبع: Journal of Biomaterials Science, Polymer Edition : Volume 26, Issue 18, 2015 , Pages 1439-1451
نمایه شده در: WOS Crossref Pubmed Scopus
شناسه دیجیتال: DOI:10.1080/09205063.2015.1100496
شناسه اختصاصی:
IRDOI
583-337-938-680
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لینک دانلود: [درخواست از نویسنده برای دریافت منبع] [دانلود از طریق گوگل اسکالر]
لینک ناشر: http://dx.doi.org/10.1080/09205063.2015.1100496
چکیده توضیحات بیشتر پیشنهاد ادامه پژوهش پیوست‌ها

The body cant control massive bleeding without treatment. Different hemostatic agents have been prepared recently, but most of them are ineffective in severe bleeding and expensive or cause safety concerns. In this study, in order to achieve fast control of bleeding, we synthesized and characterized fast-swelling porous superabsorbent hydrogel (FSPSH) and investigated its use as a hemostatic agent. The FSPSH was prepared by grafting acrylic acid and acrylamide onto starch through free-radical polymerization in aqueous solution. The FSPSH was characterized by Fourier transform infrared, X-ray diffraction, field emission scanning electron microscope, and thermogravimetric analysis. Then, temporal swelling behavior and coagulation time experiments were used to predict the in vivo behavior of the FSPSH. The hemocompatibility of synthesized FSPSH was evaluated by hemolysis test and blood cells function. In vivo study using femoral artery injury in rat demonstrated the FSPSHs ability to aid in rapid hemostasis. Furthermore, monitoring the rat on first and seventh day after femoral artery injury also showed no harmful effect. This study indicates that FSPSH adsorbs fluid and swells, thus forms a physical barrier to blood loss. FSPSH, moreover, as hemostat is simple to use, lightweight, stable, and harmless. © 2015 Taylor and Francis.
Keywords
blood cell Superabsorbent hydrogel chemical composition Microscopy, Electron, Scanning rat Synthesis and characterizations materials testing Acrylamide Swelling scanning electron microscopy Swelling behavior Hemostatics Humans starch thermogravimetry human femoral artery disease model Materials Testing acrylic acid Fourier transform infra reds acrylic acid derivative bleeding hemocompatibility Free radical polymerization infrared spectroscopy Solutions Animals injuries Thermogravimetric analysis controlled study adult hemolysis Rats Water hydrocolloid dressing animal hydrogel blood clotting fast swelling porous superabsorbent hydrogel human cell Bandages, Hydrocolloid Disease Models, Animal Polymerization hemostasis Article Femoral Artery biomaterial Thermogravimetry fast-swelling hydrogel hemostatic ability biocompatibility nonhuman chemistry polymerization Acrylic monomers Spectroscopy, Fourier Transform Infrared Acrylates Porosity cross linking Scanning electron microscopy in vivo study thermostability Hemocompatibility X-Ray Diffraction solution and solubility Free radicals Blood Hydrogels Field emission scanning electron microscopes animal model animal experiment blood clotting time priority journal porosity hemostatic agent artery injury erythrocyte Starch synthesis X ray diffraction acrylamide water

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