Sasanian art includes rock reliefs, textiles, painting, stucco, architecture, and silver each medium represents an example of the combination of different cultures' motifs to create new range of meanings. Like the mix of peoples and art within the Sasanian Empire, several religions existed simultaneously. The four hundred years of Sasanian rule, the Persians were the dominant culture of the Silk Road, and thus the trade between the east and the west, most of the civilizations of the ancient world had to pass through Iran. Sasanian Persia was the most important intermediary for luxury goods such as silk and spices reaching Rome from as far as China, and from the early fifth century on it was also a source of both artistic motifs and luxury goods. The cultural legacy of the Sasanian art in turn became a great source of inspiration for Roman and Byzantine art and Asia. This paper seeks to explore and explain the term Sasanian art and to give a new face to their influence on Roman and Byzantine art that were caught in this ancient clash of civilizations .In addition, importance in Sasanian painting represents one of the aspects of Sasanian art because of the extremely fragmentary state of the wall‐paintings recovered in Iran .This was a historical research, in which data collected from written sources was analyzed using a descriptive-analytic approach.