Background: Epilepsy is one of the common diseases affect some cognitive functions such as perception, attitudes and subjective well-being. Therefore, this study aimed to investigate the relationship between cognitive factors with subjective well-being among people with epilepsy, and also develop a structural equation model for this relevance. Methods: This was a descriptive study of the type of structural equation modeling. This study population was people over 14 years old suffered from epilepsy and referred to Isfahan’s epilepsy charity, Iran, in the year of 2016; 120 of them were chosen via available sampling method. Research tools included subjective well-being questionnaire, dysfunctional attitude questionnaire, perception of illness questionnaire, and cognitive errors questionnaire. To analyze the results of this study, SPSS and AMOS software were used. Findings: There was a good fit with the default model. Analysis of the original model indicated that understanding the emotional response to the disease (β = 0.81), the confidence to treat (β = 0.66), cognitive errors (β = 0.53), and dysfunctional attitude scale (DAS) (β = -0.42) were correlated with subjective well-being. In addition, understanding the emotional response to the disease (0.65), the confidence to treat (0.43), cognitive errors (0.28), and dysfunctional attitude scale (0.1.7) were involved in patients’ subjective well-being. Conclusion: The results show that subjective well-being in patients with epilepsy greatly appreciates the understanding emotional response to the disease and the confidence in the treatment. So, that is necessary for therapists to pay attention to these two factors beside the medical treatments. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.