The birth of the first in vitro fertilized baby, followed by further advances in the field of assisted reproductive technology (ART) has made this technology one of the most attractive tourism innovations among the different categories of medical tourism. In addition, factors such as legal, moral, religious and ethical issues play important roles in choosing reproductive tourism destinations. The aim of this study was to examine the factors influencing destination choice in infertile couples who referred to the Isfahan Fertility and Infertility Center in Isfahan, Iran. Field evaluation was carried out based on a documentary survey and questionnaire completed by interviewers. Among a target group of 80 infertile couples, 67 were interviewed. The majority of participants in this study were Muslim couples who traveled for reproductive tourism to Iran. It can be concluded that religious affinity may have paramount importance in reproductive medical tourism for Muslim infertile couples. © 2011 Elsevier Ltd.