Author(s)
Kariminik A. Kennedy D. Dabiri S.

Title: The role of CXCR3 and its ligands in renal transplant outcome

Author(s): Kariminik A.,Kennedy D.,Dabiri S.
منبع: European Cytokine Network : Volume 27, Issue 2, 2016 , Pages 16-22
نمایه شده در: Pubmed WOS Crossref Scopus
شناسه دیجیتال: DOI:10.1684/ecn.2016.0375
شناسه اختصاصی:
IRDOI
383-790-803-647
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لینک دانلود: [درخواست از نویسنده برای دریافت منبع] [دانلود از طریق گوگل اسکالر]
لینک ناشر: http://dx.doi.org/10.1684/ecn.2016.0375
چکیده توضیحات بیشتر پیشنهاد ادامه پژوهش پیوست‌ها

Chemokines and their corresponding receptors serve as pro-inflammatory and migratory signals for immune cells. CXCR3 and its corresponding ligands, CXCL9, CXCL10 and CXCL11, participate in the induction of immune responses against several foreign antigens. Numerous cells, including macrophages, NK cells and T lymphocytes, express CXCR3 and thus, expression of the receptor and its ligands can induce activity of these important immune cells against foreign antigens, including allogeneic grafts. Several parameters of the immune system participate in the induction and stimulation of powerful immune responses against allogeneic grafts. A thorough understanding of the parameters that regulate these responses can provide insights into new methods for immunotherapy during organ transplantation. The aim of this review is to address the most recent information regarding the roles played by CXCR3 and its corresponding ligands in the outcome of renal transplantation. © 2016 John Libbey Eurotext.
Keywords
allograft chemokine mitogen activated protein kinase immune system T lymphocyte subpopulation T-Lymphocyte Subsets CXCL4 chemokine CXCL9 focal adhesion kinase 1 cell migration treatment outcome Humans CXCL10 kidney disease Ligands immunoglobulin enhancer binding protein human chemokine receptor CXCR3 Treatment Outcome natural killer cell CXCL4L1 chemokine Transplantation Graft Rejection graft survival Animals ligand alpha chemokine cell survival immunocompetent cell Receptors, CXCR3 graft rejection CXCL11 gamma interferon inducible protein 10 melanoma differentiation associated gene 5 protein peptides and proteins macrophage unclassified drug organ transplantation Chemokines, CXC outcome assessment nonhuman immunology CXCL11 chemokine dendritic cell G protein coupled receptor CXCL9 chemokine kidney graft rejection Graft Survival cell proliferation kidney transplantation CXCR3 Review upregulation metabolism genetics Kidney Diseases animal Kidney Transplantation

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