Background and research. Low back pain is the most common pain in the population of patients affected by chronic pain. Logo therapy tries to direct people to a goal that is meaningful to live. this study aimed to determine the effect of logo therapy on the quality of life in patients with chronic low back pain. Materials and Methods. This study was a clinical trial study with pre-test-post-test and follow-up with the control group. 80 patients who had been suffering from back pain randomly divided into two groups. the quality of life questionnaire was completed by all subjects for 3 times. Findings. The quality of life scores of the test group significantly increased from 66.00 at pre-test to 80.29 at the post-test. Meanwhile, the average score of the control group was 63.85 at pre-test, 64.65 at post-test and 64.04 at follow up period, which did not change much. Conclusion. Therefore, in the treatment of patients with chronic low back pain, in addition to common medical treatments, non-pharmacological treatments such as logo therapy can also be used. © 2019 Institute of Social Development and Policy Research, Seoul National University.