Title: Immunosuppressive activity of buxidin and E-buxenone from buxus hyrcana

Author(s): Ahmad A.,Ayatollahi S.A.M.,Halim S.A.,Mesaik M.A.,Choudhary M.I.,Shahnaz S.,Murad S.,Ul-Haq Z.

منبع: Chemical Biology and Drug Design : Volume 75, Issue 3, 2010 , Pages 310-317
نمایه شده در: Pubmed Crossref WOS Scopus

شناسه دیجیتال: DOI:10.1111/j.1747-0285.2009.00906.x
شناسه اختصاصی:
IRDOI
140-678-972-827
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Buxidin (1) and E-Buxenone (2), steroidal alkaloids from Buxus hyrcana, are found to possess potent immunosuppressive properties. The activity was tested in vitro on oxidative burst, chemotaxis, T-cell proliferation, and cytokine production. Both compounds showed a significant immunomodulatory activity with clear suppressive effect on oxidative burst and chemotaxis in a dose-dependent manner. They also exhibited suppressive effect on the phytohemagglutinin- stimulated T-cell proliferation. The immunomodulatory activity was further confirmed by the suppression of IL-2 and IL-4 production. Furthermore, molecular docking studies were performed to investigate the binding mode of Buxidin (1) and E-Buxenone (2) with IL-2. Despite the structural differences between Buxidin (1) and E-Buxenone (2), docking results revealed that they adopt a similar binding pattern at the active site of the IL-2. A good agreement between practical and theoretic results indicates that the current docking study could provide an alternate tool for the structural optimization of recently identified ligand as more potent IL-2 inhibitors. © 2010 John Wiley & Sons A/S.

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